- Outcomes of Surgical Resection for Ruptured Hepatocellular Carcinoma
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Hae Won Lee, Chang-Sup Lim, Hyo-Sin Kim
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J Liver Cancer. 2017;17(1):54-59. Published online March 31, 2017
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DOI: https://doi.org/10.17998/jlc.17.1.54
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Abstract
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- Background/Aim
s: Many recent studies have shown excellent outcomes of surgical resection
for ruptured hepatocellular carcinoma (HCC). In addition, there are several reports suggesting
that a ruptured HCC did not increase the risk for peritoneal dissemination of a tumor after
surgical resection. However, the impact of HCC rupture on recurrence and patient survival has
not yet been clarified.
Methods The medical data of patients who underwent surgical resection for ruptured HCC
in our center between January 2011 and December 2015 were retrospectively reviewed. The
outcomes of the patients were investigated.
Results Among 128 patients who underwent surgical resection for HCC, 5 patients (3.9%) had
a ruptured HCC. All patients underwent elective operation in a stable condition. Transarterial
chemoembolization (TACE) was performed for achieving hemostasis in four patients except
one who achieved spontaneous hemostasis. Two patients had tumor recurrence and one
patient died due to HCC recurrence during the median follow-up duration of 28.3 months
(range, 24.3–62.3 months). One patient who developed late intrahepatic recurrence at 40.0
months after resection was managed well by means of radiofrequency ablation and TACE and
is now alive for 5 years without any evidence of viable tumor. However, the other patient who
showed early peritoneal seeding at 1.9 months after resection finally died despite aggressive
treatments.
Conclusions Rupture of HCC might result in peritoneal seeding of the tumor in the early
postoperative stage, which could lead to a poor result. Nonetheless, surgical resection may be
the best treatment option yielding good survival, even for a ruptured HCC.
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Citations
Citations to this article as recorded by
- Ruptured Massive Hepatocellular Carcinoma Cured by Transarterial Chemoembolization
Ji Eun Lee, Joong-Won Park, In Joon Lee, Bo Hyun Kim, Seoung Hoon Kim, Hyun Beom Kim Journal of Liver Cancer.2020; 20(2): 154. CrossRef
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